Phenylacetyl chloride → HCID 67916020, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of (3aRS,7aRS)-7,7-bis-(3-tolyl)-4-perhydroisoindolone hydrochloride (1.5 g) in dichloromethane (30 cc) cooled to +4° C. is treated with triethylamine (1.15 cc) and then with phenylacetyl chloride (0.63 g). The reaction mixture is stirred for 5 hours at 25° C. and then washed with water (3×100 cc). The organic phase is dried over magnesium sulphate and filtered and the filtrate is concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallized twice from acetonitrile to give (3aRS,7aRS)-7,7-bis-(3-tolyl)-2-(phenylacetyl)-4-perhydroisoindolone (0.36 g). m.p.=207° C.

Provenance & Evidence