反应详情

7.13 g (0.04 mol) of 4-benzyloxy-2-buten-1-ol was dissolved in 250 ml of dichloromethane and 8.6 g (0.04 mol) of m-chloroperbenzoic acid (purity: 80%) was added thereto in four portions under ice-cooling and stirring. After stirring the mixture at the same temperature for additional 1 hour, the precipitate thus formed was filtered off. The filtrate was poured into a 10% aqueous solution of sodium hydrosulfite, extracted with dichloromethane, washed with water, and dried. After distilling off the solvent, the obtained liquid residue was purified by column chromatography (silica gel, hexane/ether) to thereby give 7.7 g of 4-benzyloxy-2,3-epoxybutan-1-ol as a colorless liquid.

1. temperaturein four portions under ice-cooling
2. stirringAfter stirring the mixture at the same temperature for additional 1 hour
3. customthe precipitate thus formed
4. filtrationwas filtered off
5. additionThe filtrate was poured into a 10% aqueous solution of sodium hydrosulfite
6. extractionextracted with dichloromethane
7. washwashed with water
8. customdried
9. distillationAfter distilling off the solvent
10. customthe obtained liquid residue was purified by column chromatography (silica gel, hexane/ether)