3,4-Bis(chloromethyl)pyridine → HCID 86741739, compound

HRID 1030040Notes

Reaction equation

HRID 1030040 reaction equation
P(OP(O)=O)(O)=O.C(C(C(C)C)(C(C)C)C(C)C)(C)C.[CH2:21]1[C:29]2[C:25](=[CH:26][C:27]([P:40]([O:46]C(C)C)(=[O:45])[O:41]C(C)C)([P:30]([O:36]C(C)C)(=[O:35])[O:31]C(C)C)[CH:28]=2)[CH:24]=[CH:23][NH:22]1.ClCC1C=NC=CC=1CCl>>[CH2:21]1[C:29]2[C:25](=[CH:26][C:27]([P:30]([OH:35])(=[O:31])[OH:36])([P:40]([OH:46])(=[O:41])[OH:45])[CH:28]=2)[CH:24]=[CH:23][NH:22]1

Participants

4

Reactant 3

HCID 145187553,4-Bis(chloromethyl)pyridineHCID 86741740HCID 86741740, compoundHCID 178443211HCID 178443211, compound

Product 1

HCID 86741739HCID 86741739, compound

Procedure

Using the same procedure as in Example VII, tetraisopropyl methane diphosphonate is converted to tetraisopropyl dihydro-2-pyrindine-6,6-diphosphonate by reaction with 3,4-bis(chloromethyl)pyridine. The resulting ester is hydrolyzed as in Example VII to yield the dihydro-2-pyrindine-6,6-diphosphonic acid.

Sources & evidence

ORD record
ord-d7bf764196a34bd89466c8ba84929222
Source dataset
uspto-grants-1992_04
Patent number
US05104863

Reaction notes

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