Hexane → HCID 178448368, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4S)-3,3-diethyl-1-[(R)-α-n-propyl-(4-methyl)-benzylaminocarbonyl]-4-[4-(bromomethyl)phenoxy]-azetidin-2-one (203 mg, 0.40 mmol) and diethyl phenylphosphonite (155 μL, 0.81 mmol) was heated for 1 hour at 80° C. The desired product was obtained pure after flash chromatography on silica gel using initially 33% ethyl acetate in hexane and subsequently 50% ethyl acetate in hexane as the mobile phase; yield 223 mg (93%); FAB MS m/z 591 (M+1).

Provenance & Evidence