3,5-Difluoropropiophenone → HCID 10490818, compound

HRID 1030044Notes

Reaction equation

HRID 1030044 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:12])[CH2:10][CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br-:13].[Br-].O1CCOCC1>O1CCOCC1>[Br:13][CH:10]([CH3:11])[C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:12]

Participants

4

Reactant 2

HCID 1456203,5-DifluoropropiophenoneHCID 222259191,4-Dioxane dibromide

Product 1

HCID 10490818HCID 10490818, compoundYield 102.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 3',5'-difluoropropiophenone (56.0 g. 0 33 mole) was added a solution of dioxane dibromide (81.8 g. 0.33 mole) in dioxane (500 ml) The reaction mixture was worked up as in Example 1 to yield crude 2-bromo-3',5'-difluoropropiophenone (83.9 g).

Sources & evidence

ORD record
ord-21d907bf68314712b9ddd63ff1c444f7
Source dataset
uspto-grants-1992_04
Patent number
US05104870

Reaction notes

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