Carbon Dioxide → HCID 131717276, compound

Participants

Reaction Steps

To a solution of 7-[2-allyloxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) (1.15 g) in 50% aqueous acetone (9.2 ml) was added sodium hydrogencarbonate (193 mg) and dry ice (4.4 g) at room temperature. The mixture was stirred in a sealed tube for 5 hours. Acetone was removed under reduced pressure. The residual solution was chromatographed on non-ionic adsorption resin "Diaion HP-20" (Trademark, maker: Mitsubishi Chemical Industries) eluting with water. The desired fractions were collected and lyophilized to give sodium 7-[2-allyloxyimino-2-(5-carboxylatoamino-1,2,4-thiadiazol-3-yl)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) (500 mg).

Provenance & Evidence