Sodium Bicarbonate → HCID 131717282, compound

Participants

Reaction Steps

To a suspension of crystals of 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-(4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate sulfate (syn isomer) (500 mg) in 50% aqueous acetone (4 ml) was added sodium hydrogencarbonate (323 mg) at ambient temperature. Carbonic acid gas was bubbled into the mixture for four hours and diluted with water. The resulting mixture was chromatographed on non-ionic adsorption resin "Diaion HP-20" (50 ml) eluting with water. The desired fractions were collected and lyophilized to give sodium 7-[2-(5-carboxylatoamino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-(4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate (syn isomer) (239.6 mg).

Provenance & Evidence