Nitric Acid → HCID 15685404, compound

HRID 1030065Notes

Reaction equation

HRID 1030065 reaction equation
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]([F:19])([F:18])[C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:8]=1[Br:17]>S(=O)(=O)(O)O>[N+:1]([C:9]1[C:8]([Br:17])=[C:7]([C:6]([F:5])([F:18])[F:19])[CH:12]=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:10]=1)([O-:4])=[O:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 1361642,4-Bis(trifluoromethyl)bromobenzene

Product 1

HCID 15685404HCID 15685404, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
80 °C

Procedure

Concentrated nitric acid (2.6 ml) was cautiously added to a solution of 2,4-bis(trifluoromethyl)bromobenzene (16 g) in concentrated sulphuric acid (48 ml), and the mixture was heated to 80° C. for 6 hours. After cooling to ambient temperature and allowing to stand overnight, the reaction mixture was cautiously poured onto ice, and extracted with ethyl acetate. The organic extracts were washed with water and brine and dried over magnesium sulphate. Evaporation of the solvent, under reduced pressure, gave 6-nitro-2,4-bis(trifluoromethyl) bromobenzene as a yellow liquid.

Workup

  1. temperatureAfter cooling to ambient temperature
  2. additionthe reaction mixture was cautiously poured onto ice
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with water and brine
  5. dry with materialdried over magnesium sulphate
  6. customEvaporation of the solvent

Sources & evidence

ORD record
ord-f6f3d76bd2cc4b4688d965b1711cbb8a
Source dataset
uspto-grants-1992_04
Patent number
US05104878

Reaction notes

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