3-chloro-4-(trifluoromethoxy)benzamide → 3-chloro-4-(trifluoromethoxy)benzonitrile
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([NH2:7])=O>O=S(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:13])([F:14])[F:15])[C:5]#[N:7]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 85 °C
Procedure
750 ml of SOCl2 were added to 239.5 g (1 mol) of 3-chloro-4-trifluoromethoxybenzamide and the mixture was heated slowly (corresponding to the evolution of gas) to 85° C. The mixture was then fractionally distilled and 189 g of product having a boiling point at 13 mbar of 96° C. and a melting point of 38° to 40° C. were obtained. This corresponds to a yield of 85% of theory.
Workup
- distillationThe mixture was then fractionally distilled
- customat 13 mbar of 96° C.
- customa melting point of 38° to 40° C. were obtained
Sources & evidence
- ORD record
- ord-ad79efa0e84b4743834490f2c901e2eb
- Source dataset
- uspto-grants-1992_04
- Patent number
- US05104879
Reaction notes
Loading…