HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1030101Generated: November 3, 2026
Dimethylformamide → 4-(1H-1,2,4-triazole-1-yl)-2-methyl-6-methoxy-quinoline
https://huagongshe.com/reaction/1030101
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-Chloro-6-methoxy-2-methylquinoline hydrochloride | HCID 19822133 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(1H-1,2,4-triazole-1-yl)-2-methyl-6-methoxy-quinoline | HCID 14837826 | 87% |
Reaction Steps
A mixture of 2.44 g of 2-methyl-4-chloro-6-methoxy-quinoline-hydrochloride, 1.38 g of 1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 80° C. for 3 hours whereupon the reaction mixture is poured into 100 ml of water and neutralized with 2 ml of a concentrated ammonium hydroxide solution. The precipitated product is filtered. Thus 2.09 g of the desired compound are obtained, yield 87%, mp.: 117°-118° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05104884 |
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| Source dataset | uspto-grants-1992_04 |
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| ORD ID | ord-46b7782abfd1492db6b26c033b79e9fe |
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| Source note | uspto-grants-1992_04 |
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