Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | HCID 12217072 | HCID 12217072 | — |
| Reactant | 2-Chloro-7-ethyl-3-methylquinoline | HCID 17039814 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 14837870 | HCID 14837870 | 64.1% |
Reaction Steps
A mixture of 2.05 g of 2-chloro-3-methyl-7-ethyl-quinoline, 1.05 g of 1,2,4-triazole-hydrochloride, 0.69 g of 1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 100° C. for 6 hours. The reaction mixture is poured into 100 ml of water, neutralized and the crude product is recrystallized from a mixture of ethanol and hexane. Thus 1.52 g of the desired compound are obtained, yield 64%. Mp.: 72°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05104884 |
|---|
| Source dataset | uspto-grants-1992_04 |
|---|
| ORD ID | ord-71b064fb08eb4986bdea8ba5795ec967 |
|---|
| Source note | uspto-grants-1992_04 |
|---|
