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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1030127Generated: November 5, 2026

1-Iodoethyl cyclohexyl carbonate → 1-(Cyclohexyloxycarbonyloxy)ethyl (1R, 5S, 6S)-2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate

https://huagongshe.com/reaction/1030127

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Iodoethyl cyclohexyl carbonateHCID 11109278—
Reactantsodium 2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylateHCID 131717290—
Product1-(Cyclohexyloxycarbonyloxy)ethyl (1R, 5S, 6S)-2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylateHCID 57289719—

Reaction Steps

Following a procedure similar to that described in Example 39, but using 54 mg of sodium 2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate obtained by a similar procedure to that described in Example 36 and 50 μl of 1-(cyclohexyloxycarbonyloxy)ethyl iodide, 62 mg of the title compound were obtained as a colorless powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05104867
Source datasetuspto-grants-1992_04
ORD IDord-478f176247b942dfb620fbcb65acb379
Source noteuspto-grants-1992_04