HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl N-cyanopropionimidate → HCID 178457586, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl N-cyanopropionimidate | HCID 10820532 | — |
| Reactant | (3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile | HCID 10943936 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178457586 | HCID 178457586 | 47% |
Reaction Steps
A mixture of trans-4-amino-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (4.37 g) and ethyl N-cyanopropionimidate (2.65 g) in ethanol (22 ml) was refluxed for 10 hours. The mixture was cooled and concentrated under reduced pressure. The residue was pulverized with ethanol and recrystallized from ethanol to give trans-4-[N-[1-(cyanoimino)propyl]amino]-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (2.81 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-ef8b4c26a3324654b19cb9e0070fa59c |
| Source note | uspto-grants-1992_04 |