Water → HCID 14627830, compound

Participants

Reaction Steps

2,6-Di-tert-butyl-4-[(4-ethoxycarbonylmethyl-2-thiazolyl)oxy]phenol (produced in Example 41) (0.40 g) was dissolved in 15 ml of ethanol, 8 ml of 2 N aqueous sodium hydroxide was added to the solution at room temperature, and the mixture was stirred for 1 hour. The reaction mixture was poured into water and, after acidification to Congo red with 36% hydrochloric acid, extracted with dichloromethane. The organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated. The crude product obtained was washed with diethyl ether-hexane (1:10) to give 0.30 g of the desired compound as a colorless solid.

Provenance & Evidence