Water → HCID 14627833, compound

Participants

Reaction Steps

Lithium aluminum hydride (0.40 g) was suspended in 100 ml of diethyl ether, a solution (30 ml) of 0.80 g of 2,6-di-tert-butyl-4-[(4-ethoxycarbonyl-2-thiazolyl)oxy]phenol (produced in Example 40) in tetrahydrofuran was added to the suspension with stirring at room temperature, and the resultant mixture was stirred for further 4 hours. Water and then magnesium sulfate were added to the reaction mixture with cooling in an ice bath, and the resultant mixture was stirred for 15 minutes. The insoluble matter was filtered off, and the filtrate was concentrated. The crude product obtained was recrystallized from diethyl ether-hexane to give 0.30 g of the desired product as colorless crystals.

Provenance & Evidence