反应详情

温度

10 °C

To a cooled (10° C.), stirred suspension of KOtBu (8.9 g, 0.080 mol) in DMSO (40 mL) was added a solution of 4-fluoronitrobenzene (11.2 g, 0.080 mol) and 3-chloropropanethiol (8.8 g, 0.080 mol) in DMSO (40 mL) over 10 minutes. The mixture was stirred at room temperature for 3.5 hours, diluted with water (1000 ml), and extracted with ether. The extracts were washed with brine, dried (MgSO4), and concentrated. Purification by flash chromatography (10% EtOAc/hexane) gave 6.2 g (34%) of product as a yellow solid m.p. 45°-48° C.

1. stirringThe mixture was stirred at room temperature for 3.5 hours
2. extractionextracted with ether
3. washThe extracts were washed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customPurification by flash chromatography (10% EtOAc/hexane)