HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-[4-(3-Methylamino-1-propylthio)phenyl]methanesulfonamide Hydriodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N-[4-(3-Iodo-1-propylthio)phenyl]methanesulfonamide | HCID 19822344 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(3-Methylamino-1-propylthio)phenyl]methanesulfonamide Hydriodide | HCID 86745676 | 94% |
Reaction Steps
A solution of N-[4-(3-iodo-1-propylthio)phenyl]methanesulfonamide (4.8 g, 0.13 mol), THF (28 mL), and 40 wt % methylamine in water (56 mL) was stirred at room temperature for 2 hours. The mixture was concentrated, taken up in 2:1 EtOH/toluene, and concentrated to give 4.9 g (94%) of product as a brown solid m.p. 80°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104892 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-44848985704642caa09ce32dec9af53c |
| Source note | uspto-grants-1992_04 |