HCID 86745671, compound → HCID 19102849, compound

HRID 1030284Notes

Reaction equation

HRID 1030284 reaction equation
C([O:3][C:4]([C:6]1[C:36](=[O:37])[C:35]([C:38]([O:40]CC)=[O:39])=[CH:34][C:9]2[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([O:32]C)=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:12][C:8]=2[CH:7]=1)=[O:5])C>[OH-].[Na+].C(O)C>[C:4]([C:6]1[C:36](=[O:37])[C:35]([C:38]([OH:40])=[O:39])=[CH:34][C:9]2[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([OH:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:12][C:8]=2[CH:7]=1)([OH:5])=[O:3]

Participants

4

Reactant 1

HCID 86745671HCID 86745671, compound

Product 1

HCID 19102849HCID 19102849, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

An aliquot of the triester from Step (h) (300 mg) was hydrolyzed by stirring it in a mixture of 12 ml of 10% sodium hydroxide and 12 ml of ethanol for 6 h at 40° C. The azeotrope was distilled off, water (30 ml) was added and the resulting solution slowly acidified to pH 3 with HCl 2N. The resulting precipitated acid was isolated (mp 186, decomp.).

Workup

  1. distillationThe azeotrope was distilled off
  2. additionwater (30 ml) was added
  3. customThe resulting precipitated acid
  4. customwas isolated (mp 186, decomp.)

Sources & evidence

ORD record
ord-190036e7fc084f6291ef4b87121a10fd
Source dataset
uspto-grants-1992_04
Patent number
US05104891

Reaction notes

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