Sulfolane → HCID 19822222, compound

HRID 1030353Notes

Reaction equation

[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH:33](Cl)[C:34](OCC)=[O:35])=[CH:28][CH:27]=1)([CH3:23])[CH2:9][CH2:8]2)(=[O:3])[CH3:2].[NH2:40][C:41](N)=[S:42].S1(CCCC1)(=O)=[O:45]>>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:18])([CH3:20])[CH3:19])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH:33]3[S:42][C:41](=[O:45])[NH:40][C:34]3=[O:35])=[CH:28][CH:27]=1)([CH3:23])[CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 31347Sulfolane

HCID 2723790Thiourea

HCID 19822261HCID 19822261, compound

Product 1

HCID 19822222HCID 19822222, compound

Procedure

The procedure described in Example 2 was repeated, but using 7.0 g of ethyl 3-{4-[6-acetoxy-2-methyl-7-(1,1,3,3-tetramethylbutyl)chroman-2-ylmethoxy]phenyl}-2-chloropropionate (prepared as described in Preparation 23), 1.2 g of thiourea and 9 ml of sulfolane, to give the title compound as slightly yellow glassy solid, softening at 75°-80° C.

Sources & evidence

ORD record: ord-1c8ab1ab6f9b486e8983b3753f345625
Source dataset: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05104888

Reaction notes

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