Sulfolane → HCID 19822270, compound

HRID 1030355Notes

Reaction equation

[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH:33](Cl)[C:34](OCC)=[O:35])=[CH:28][CH:27]=1)([CH3:23])[CH2:9][C:8]2=[O:40])(=[O:3])[CH3:2].[NH2:41][C:42](N)=[S:43].S1(CCCC1)(=O)=[O:46]>>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH:33]3[S:43][C:42](=[O:46])[NH:41][C:34]3=[O:35])=[CH:28][CH:27]=1)([CH3:23])[CH2:9][C:8]2=[O:40])(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 31347Sulfolane

HCID 2723790Thiourea

HCID 19822190HCID 19822190, compound

Product 1

HCID 19822270HCID 19822270, compound

Procedure

The procedure described in Example 2 was repeated, but using 7.3 g of ethyl 3-{4-[6-acetoxy-2-methyl-4-oxo-7-(1,1,3,3-tetramethylbutyl) chroman-2-ylmethoxy]phenyl}-2-chloropropionate (prepared as described in Preparation 25), 1.3 g of thiourea and 8 ml of sulfolane, to give the title compound as a slightly yellow powder, softening at 80° -88° C.

Sources & evidence

ORD record: ord-e533f16198f04c37aca60812a001a4ba
Source dataset: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05104888

Reaction notes

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