HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-5-methylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 3-[4-(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)phenyl]-2-chloro-2-methylpropionate | HCID 19822192 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-5-methylthiazolidine-2,4-dione | HCID 19822218 | — |
Reaction Steps
The procedure described in Example 3 was repeated, but using 1.17 g of ethyl 3-[4-(6-acetoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]-2-chloro -2-methylpropionate (prepared as described in Preparation 46), 0.63 g of thiourea, 3 g of sulfolane, 10 ml of ethylene glycol monomethyl ether, 3 ml of water and 2 ml of 35% w/v aqueous hydrochloric acid, to give the title compound, softening at 69°-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104888 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-ad184ec603eb460c8962ff3534d3c159 |
| Source note | uspto-grants-1992_04 |