HCID 19822219, compound → HCID 19822170, compound

HRID 1030378Notes

Reaction equation

HRID 1030378 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:39]=[CH:38][C:12]([O:13][CH2:14][C:15]3([CH3:37])[CH:24]=[CH:23][C:22]4[C:17](=[C:18]([CH3:36])[C:19]([CH3:35])=[C:20]([O:26][CH2:27][C:28]([O:30][CH2:31][CH2:32][O:33][CH3:34])=[O:29])[C:21]=4[CH3:25])[O:16]3)=[CH:11][CH:10]=2)[S:3]1>[Pd].C(O)C>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([O:13][CH2:14][C:15]3([CH3:37])[CH2:24][CH2:23][C:22]4[C:17](=[C:18]([CH3:36])[C:19]([CH3:35])=[C:20]([O:26][CH2:27][C:28]([O:30][CH2:31][CH2:32][O:33][CH3:34])=[O:29])[C:21]=4[CH3:25])[O:16]3)=[CH:38][CH:39]=2)[S:3]1

Participants

4

Reactant 1

HCID 19822219HCID 19822219, compound

Product 1

HCID 19822170HCID 19822170, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Using Paar's hydrogenation apparatus, a mixture of 260 mg of 2-methoxyethyl α-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-2,5,7,8-tetramethyl-2H-chromen-6-yloxy}acetate (prepared as described in Example 39), 300 mg of 10% w/v palladium-on-carbon and 50 ml of ethanol was stirred for 10 hours under a hydrogen pressure of 3-5 atmospheres. The palladium-on-carbon was then filtered off, and the filtrate was condensed by evaporation under reduced pressure, to give the title compound as a colorless oily substance.

Workup

  1. filtrationThe palladium-on-carbon was then filtered off
  2. customcondensed
  3. customby evaporation under reduced pressure

Sources & evidence

ORD record
ord-3a97adb44a6a45c8a1fa6553bedfae01
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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