HCID 19822179, compound → HCID 19822264, compound

HRID 1030396Notes

Reaction equation

HRID 1030396 reaction equation
[C:1]([O:4][C:5]1[C:6]([CH3:33])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:28][CH:29]([CH3:31])[CH3:30])([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=1)[CH2:9][C:8]2=[O:32])(=[O:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:4][C:5]1[C:6]([CH3:33])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)([CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:9][C:8]2=[O:32])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 19822179HCID 19822179, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19822264HCID 19822264, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.4 g of 6-acetoxy-2-isobutyl-5,7,8-trimethyl-2-(4-nitrophenoxymethyl)chroman-4-one (prepared as described in Preparation 7) was dissolved in 35 ml of methanol, and, in the presence of 1 g of 10% w/w palladium-on-carbon, it was reduced for 3 hours under about 1 atmosphere (about 1 bar) pressure of hydrogen. The catalyst was filtered off, and the solvent was then distilled off under reduced pressure to give the title compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was then distilled off under reduced pressure

Sources & evidence

ORD record
ord-5381b877f9f6455ab99634ac85ae14d1
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

Loading…