Hydrochloric Acid → HCID 19822214, compound

Participants

Reaction Steps

10 ml of tetrahydrofuran containing 3.3 g of ethyl 6-methoxymethoxy-5,7,8-trimethyl-2-octylchroman-2-carboxylate (prepared as described in Preparation 12) were added dropwise to a mixture of 0.45 g of lithium aluminum hydride and 30 ml of tetrahydrofuran under a nitrogen stream, and whilst ice-cooling. The resulting mixture was stirred for 3 hours at room temperature. Ethyl acetate and 5% w/v aqueous hydrochloric acid were then added to the reaction mixture, whilst ice-cooling, and the organic layer was separated. Then the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, to give the title compound.

Provenance & Evidence