Benzene → HCID 19822253, compound

HRID 1030403Notes

Reaction equation

HRID 1030403 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[OH:8][C:9]1[C:10]([CH3:40])=[C:11]2[C:16](=[C:17]([CH3:20])[C:18]=1[CH3:19])[O:15][C:14]([CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:13][CH2:12]2.N1C=CC=CC=1.C1C=CC=CC=1>O>[C:1]([O:8][C:9]1[C:10]([CH3:40])=[C:11]2[C:16](=[C:17]([CH3:20])[C:18]=1[CH3:19])[O:15][C:14]([CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:13][CH2:12]2)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 241BenzeneHCID 1049PyridineHCID 7918Acetic AnhydrideHCID 19822242HCID 19822242, compound

Product 1

HCID 19822253HCID 19822253, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.2 g of acetic anhydride was added to a mixture of 3.5 g of 6-hydroxy-5,7,8-trimethyl-2-(4-nitrophenoxymethyl)-2-octylchroman (prepared as described in Preparation 15), 10 ml of pyridine and 10 ml of benzene, and the mixture was stirred for 2hours at room temperature. The reaction mixture was then poured into water and extracted with benzene. The extract was washed with 5% w/v aqueous hydrochloric acid and water, successively in that order, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, to give the title compound.

Workup

  1. extractionextracted with benzene
  2. washThe extract was washed with 5% w/v aqueous hydrochloric acid and water, successively in that order
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-55b4a0048f3042e68d3eba89f48a4109
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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