HCID 19822235, compound → HCID 19822255, compound

Participants

Reaction Steps

Using Paar's hydrogenation apparatus, a mixture of 9.1 g of 6-acetoxy-2-methyl-2-(4-nitrophenoxymethyl)-7-(1,1,3,3-tetramethylbutyl)-2H-chromene (prepared as described in Preparation 21), 2g of 10% w/w palladium-on-carbon and 150 ml of methanol was stirred for 10 hours under 3-5 atmospheres (about 3-5-bars) pressure of hydrogen. The catalyst was filtered off, and the filtrate was condensed by evaporation under reduced pressure. The residue was purified by silica gel column chromatography, eluted with a 10:1 by volume mixture of benzene and ethyl acetate, to give the title compound.

Provenance & Evidence