HCID 19822228, compound → HCID 19822224, compound

HRID 1030415Notes

Reaction equation

HRID 1030415 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH3:31])([CH2:19][O:20][C:21]1[CH:26]=[C:25]([N+:27]([O-])=O)[CH:24]=[CH:23][C:22]=1[CH3:30])[CH2:9][C:8]2=[O:32])(=[O:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:19][O:20][C:21]1[CH:26]=[C:25]([NH2:27])[CH:24]=[CH:23][C:22]=1[CH3:30])([CH3:31])[CH2:9][C:8]2=[O:32])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 19822228HCID 19822228, compound

Product 1

HCID 19822224HCID 19822224, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Following the same procedure as described in Preparation 24, hydrogenation of 7.3 g of 6-acetoxy-7-t-butyl-2-methyl-2-(2-methyl-5-nitrophenoxymethyl)chroman-4-one (prepared as described in Preparation 40) in the presence of 1 g of 10% w/w palladium-on-carbon and 100 ml of ethanol gave the title compound as a slightly red, foamy substance.

Sources & evidence

ORD record
ord-b9424bb3c0b2464e916f73bdb00607be
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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