HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 2-chloro-3-[4-(6-ethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | 2-(4-Aminophenoxymethyl)-6-ethoxy-2,5,7,8-tetramethylchroman | HCID 19822197 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ethyl 2-chloro-3-[4-(6-ethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]propionate | HCID 19822269 | — |
Reaction Steps
The procedure described in Preparation 64 was repeated, except that 9.5 g of 2-(4-aminophenoxymethyl)-6-ethoxy-2,5,7,8-tetramethylchroman (prepared as described in Preparation 63), 10 ml of concentrated hydrochloric acid, 2.4 g of sodium nitrite, 26.8 g of ethyl acrylate, 0.4 g of cuprous oxide and 100 ml of acetone were used as the starting materials, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104888 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-aca3391237b24c81b5b1d395ff756efc |
| Source note | uspto-grants-1992_04 |