HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(Aminocarbonyl)-2-furancarboxamide → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-furancarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(Aminocarbonyl)-2-furancarboxamide | HCID 73100 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Succinate | HCID 160419 | — |
| Reactant | Quinuclidine, 3-amino-, dihydrochloride | HCID 197853 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-furancarboxamide | HCID 15616405 | — |
Reaction Steps
The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-furoylurea (0.77 g, 5 mmol), and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.58 g) was converted to the 1:1 succinate mp 156°-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05106843 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-591c9d9339804ae6a93ad0786d9c66e6 |
| Source note | uspto-grants-1992_04 |