3-Aminoquinuclidine → HCID 15616386, compound

HRID 1030485Notes

Reaction equation

HRID 1030485 reaction equation
[NH2:1][CH:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[CH:10]([O:13][C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[C:16]([N:18]=[C:19]=[O:20])=[O:17])([CH3:12])[CH3:11].C([O-])(=O)/C=C/C([O-])=O>>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[CH:2]([NH:1][C:19]([NH:18][C:16](=[O:17])[C:15]1[CH:21]=[CH:22][CH:23]=[CH:24][C:14]=1[O:13][CH:10]([CH3:11])[CH3:12])=[O:20])[CH2:3]2

Participants

4

Reactant 3

HCID 1232383-AminoquinuclidineHCID 5460307FumarateHCID 19820425HCID 19820425, compound

Product 1

HCID 15616386HCID 15616386, compound

Procedure

The above compound was prepared, following the procedure of Example 1, from 3-aminoquinuclidine (0.31 g, 2.46 mmol) and crude 2-isopropoxybenzoyl isocyanate (0.58 g, ca 2.5 mmol). The product (0.51 g) was converted to the 1:1 fumarate, mp 171°-175° C.

Workup

  1. customThe above compound was prepared

Sources & evidence

ORD record
ord-6502737d12b14412ab55a2d78c399664
Source dataset
uspto-grants-1992_04
Patent number
US05106843

Reaction notes

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