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(3R)-1-Azabicyclo(2.2.2)octan-3-amine → (R)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3R)-1-Azabicyclo(2.2.2)octan-3-amine | HCID 719215 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | 2-Methoxybenzoyl isocyanate | HCID 14119328 | — |
| 生成物 | (R)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide | HCID 15616382 | — |
反応手順
The above compound was prepared, following the procedure of Example 1, from (R)-3-aminoquinuclidine (0.63 g, 5 mmol) and 2-methoxybenzoyl isocyanate (1.33 g, 7.5 mmol). The product (1.49 g) was converted to the 1:1 fumarate, mp 158°-159° C. (dec).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05106843 |
| 出典データセット | uspto-grants-1992_04 |
| ORD ID | ord-f67c9742dea9442082ce6fe820cebaeb |
| 出典メモ | uspto-grants-1992_04 |