Maleic Acid → HCID 67899375, compound

Participants

Reaction Steps

A solution of anhydrous maleic acid (4.30 g, 0.037 mol) in methanol (12 mL) and diethyl ether (4 mL) was added to a filtered solution of (3R,4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane free base (7.60 g, 0.037 mol) in methanol (6 mL) and diethyl ether (6 mL). After ageing at 5° C. for 16 hours the hydrogen maleate salt (9.10 g) was collected, mp 126° C. (propan-2-ol). [α]21D°C. -7.0° (c=1.0, CH2Cl2). (Found: C, 56.06; H, 5.97; N, 13.04. C11H15N3O. C4H4O4 requires C, 56.07; H, 5.96; N, 13,08%).

Provenance & Evidence