HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1030529Generated: October 25, 2026
2-(Bromomethyl)-4-fluoro-1-nitrobenzene → N-(5-fluoro-2-nitrophenyl)methyl-phthalimide
https://huagongshe.com/reaction/1030529
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Bromomethyl)-4-fluoro-1-nitrobenzene | HCID 10561643 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(5-fluoro-2-nitrophenyl)methyl-phthalimide | HCID 19820552 | — |
Reaction Steps
A solution of 5-fluoro-2-nitro-benzylbromide (6.2 g) in dimethylformamide (20 ml) was dropped into a stirred suspension of potassium phthalimide (4.9 g) in the same solvent (40 ml). The mixture was heated under stirring to 90° C. for 2 hours, then cooled and diluted with water. The title compound (7.2 g) was recovered by filtration. M.p. 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05106851 |
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| Source dataset | uspto-grants-1992_04 |
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| ORD ID | ord-bab01ec25e174a5e9e8ea8ea18f37e6f |
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| Source note | uspto-grants-1992_04 |
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