1-Methylpiperazine → HCID 85645436, compound

Participants

Reaction Steps

1-Methylpiperazine (0.65 g, 6.49 mmols) was added to a stirred, cooled (ice/H2O bath) solution of 4-(2-propoxy)-3-(tri-n-butylstannyl)-cyclobut-3-ene-1,2-dione (2.53 g, 5.90 mmols) in diethyl ether (80 mL). Stirring was continued with cooling for 1 hr and then at ambient temperatures for 1 hr. The mixture was concentrated and the residue chromatographed on SiO2 with ethyl acetate-methylene chloride (35:65) to afford the title compound (2.1 g, 76% yield) as a golden viscous oil.

Provenance & Evidence