HCID 21979167, compound → HCID 69074748, compound

HRID 10306Notes

Reaction equation

[ClH:1].[NH2:2][N:3]1[C:12](=[O:13])[C:11]2[C:6](=[C:7](OC)[C:8]([N:15]3[CH2:19][CH:18]([CH:20]([NH2:22])[CH3:21])[C:17]([CH3:24])(C)[CH2:16]3)=[C:9]([F:14])[CH:10]=2)[N:5]([CH:27]2[CH2:29][CH2:28]2)[C:4]1=[O:30].[C:31]([O:35]C(=O)NC(C1C(C)(C)CN(C2C(OC)=C3C(C(=O)N(N)C(=O)N3C3CC3)=CC=2F)C1)C)(C)([CH3:33])[CH3:32]>>[ClH:1].[NH2:2][N:3]1[C:12](=[O:13])[C:11]2[C:6](=[C:7]([Cl:1])[C:8]([N:15]3[CH2:19][C@@H:18]([C:17]4[CH:24]=[CH:33][C:31]([OH:35])=[CH:32][CH:16]=4)[C@H:20]([NH2:22])[CH2:21]3)=[C:9]([F:14])[CH:10]=2)[N:5]([CH:27]2[CH2:28][CH2:29]2)[C:4]1=[O:30]

Participants

Reactant 2

HCID 21979167HCID 21979167, compound2×

HCID 69071169HCID 69071169, compound

Product 1

HCID 69074748HCID 69074748, compound

Procedure

(gggg) 3-Amino-7-[4-(1-aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione hydrochloride (Compound 86) (mp 230° C., MS ES: m/z 406 (MH+)) from {1-[1-(3-amino-1-cyclopropyl-6-fluoro-8-methoxy-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4,4-dimethylpyrrolidin-3-yl]ethyl}carbamic acid tert-butyl ester (Example 28w) using General Method A.

Sources & evidence

ORD record: ord-723272e4c50d4750ba96359bf38303f9
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07094780B1

Reaction notes

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