HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyric Acid → Ethyl dimethylhexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyric Acid | HCID 6590 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Butyl iodide | HCID 10962 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Ethyl dimethylhexanoate | HCID 3024116 | — |
Reaction Steps
A solution of isobutyric acid (45 g) in THF was added to LDA prepared at -78° C. according to the conventional manner and stirred for one hour. A solution of butyl iodine (107 g) in dry HMPA was added, and stirred at -78° C. for one hour, and at room temperature for additional one hour. The crude product obtained after the conventional work-up was distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05106869 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-7c878114a4954bfbabeda2042cb709db |
| Source note | uspto-grants-1992_04 |