Hydrochloric Acid → rac-(2R,3R)-3-amino-1,2,3,4-tetrahydronaphthalen-2-ol hydrochloride

HRID 1030636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1030636
C1([C@@H](C)C([NH:10][C@@H:11]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][C@H:12]2[OH:21])=O)C=CC=CC=1.[ClH:23]>>[ClH:23].[NH2:10][C@@H:11]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][C@H:12]1[OH:21]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 67865968HCID 67865968, Verbindung

Produkt 1

HCID 12878372rac-(2R,3R)-3-amino-1,2,3,4-tetrahydronaphthalen-2-ol hydrochloride

Versuchsvorschrift

Trans-N-[(2R)-2-phenylpropanoyl]-3-amino-1,2,3,4-tetrahydro-2-naphthalenol, diastereoisomer A (183 mg) was refluxed in 6N aqueous hydrochloric acid (20 ml) for 4 hours. The reaction mixture was evaporated in vacuo and the residue taken up in water. The aqueous solution was washed with ethyl acetate and evaporated to give a white solid which was recrystallized from a methanol/ethyl acetate mixture to yield the title compound (99 mg).

Aufarbeitung

  1. customThe reaction mixture was evaporated in vacuo
  2. washThe aqueous solution was washed with ethyl acetate
  3. customevaporated
  4. customto give a white solid which
  5. customwas recrystallized from a methanol/ethyl acetate mixture

Quellen und Nachweise

ORD-Eintrag
ord-17b1acab53094edfb923d4202f0f915a
Quelldatensatz
uspto-grants-1992_04
Patentnummer
US05106861

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