反应详情

温度

150 °C

A mixture of 128.40g (.60 moles) of phenyl-4-hydroxybenzoate and 36.97g 606 moles) of ethanolamine was heated to 150° C. while stirring under a nitrogen atmosphere. After 2 hours at 150° C. the amber melt was cooled to ~150° C. and then poured into 1000 ml of chloroform. Within a few minutes a solid yellow precipitate formed. The precipitate was isolated by vacuum filtration washed with fresh chloroform and then air dried. This material was identified by NMR and IR spectroscopy as N-(2-hydroxyethyl)-p-hydroxybenzamide. A 95% yield was obtained.

1. temperatureAfter 2 hours at 150° C. the amber melt was cooled to ~150° C.
2. customWithin a few minutes a solid yellow precipitate formed
3. customThe precipitate was isolated by vacuum filtration
4. washwashed with fresh chloroform
5. customair dried
6. customA 95% yield was obtained