3-Amino-7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride → HCID 21979462, compound

HRID 10307Notes

Reaction equation

[ClH:1].NN1C(=O)C2[C:6](=[C:7]([CH3:22])[C:8](N3CC4C(C4N)C3)=C(F)C=2)N(C2CC2)C1=O.C(OC(=O)[NH:33][CH:34]1[CH:39]2[CH:35]1C[N:37]([C:40]1[C:49]([CH3:50])=[C:48]3[C:43]([C:44](=[O:56])[N:45]([NH2:55])[C:46](=[O:54])[N:47]3[CH:51]3[CH2:53][CH2:52]3)=[CH:42][C:41]=1[F:57])[CH2:38]2)(C)(C)C>>[ClH:1].[NH2:55][N:45]1[C:44](=[O:56])[C:43]2[C:48](=[C:49]([CH3:50])[C:40]([N:37]3[CH2:38][CH:39]([CH:34]([NH2:33])[CH3:35])[C:7]([CH3:22])([CH3:8])[CH2:6]3)=[C:41]([F:57])[CH:42]=2)[N:47]([CH:51]2[CH2:53][CH2:52]2)[C:46]1=[O:54]

Participants

Reactant 2

HCID 219793023-Amino-7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride2×

HCID 69068438HCID 69068438, compound

Product 1

HCID 21979462HCID 21979462, compound

Procedure

(aaaaaa) 3-Amino-7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride (Compound 134) (mp 180–182° C., MS ES: m/z 346 (MH+)) from [3-(3-amino-1-cyclopropyl-6-fluoro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester (Example 28n) using General Method A.

Sources & evidence

ORD record: ord-78d431e5d1344941ac084e1b69f85abf
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07094780B1

Reaction notes

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