HCID 86745714, compound → HCID 86745713, compound

Participants

Reaction Steps

(1S,2S,3R,5S)-(E)-7-(4-Carbomethoxybutylidene)-2-[4(RS)-fluoro-3(RS)-hydroxy(E)-1-octenyl]-3-tetrahydropyranyloxybicyclo[3.3.0]octane (12') (0.129 g) was dissolved in methanol, into which 1N aqueous solution of sodium hydroxide (2 ml) was added, and stirred at room temperature for 6 hours. After a usual work-up (1S,2S,3R,5S)-(E)-7-(4-carboxybutylidene)-2-[4(RS)-fluoro-3(RS)-hydroxy-(E)-1-octenyl]-3-tetrahydropyranyloxybicyclo[3.3.0]octane (13') was obtained as a colorless oily product. Yield: 0.140 g

Provenance & Evidence