HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 10921407, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Propanol | HCID 1031 | — |
| Reactant | N-(4-methoxy-3-nitrophenyl)propanamide | HCID 2995377 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 10921407 | HCID 10921407 | — |
Reaction Steps
114 parts of 2-nitro-4-propionamidoanisole, 160 parts of propanol, 3.4 parts of a 30% aqueous solution of ammonia and 2 parts of a 50% suspension of palladium on activated charcoal, moist with water, in 3 parts of water are charged to an autoclave equipped with an aerating stirrer. The autoclave is pressurised with hydrogen and, at a pressure of 25 bar and a temperature of 120° C., hydrogenation is carried out for 1 hour. 2-Methoxy-5-propionamidoaniline is obtained in quantitative yield in a purity of >97% (analysis by liquid chromatography).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05107022 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-1767328e16814026b50eec24b2fa930e |
| Source note | uspto-grants-1992_04 |