Water → 3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid

HRID 1030896Notes

Reaction equation

HRID 1030896 reaction equation
[OH-].[K+].O.[C:4]1([CH2:10][O:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])[CH2:16][CH2:15]2)=[O:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[C:4]1([CH2:10][O:11][C:12]([N:14]2[CH2:15][CH2:16][CH:17]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:19]2)=[O:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 14989191Benzyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Product 1

HCID 98953153-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acidYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred and cooled (15° C.) mixture of 11.1 parts of potassium hydroxide and 96 parts of water was added dropwise a solution of 31.8 parts of ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate in 38 parts of ethanol during 20 minutes. Upon complete addition, stirring was continued overnight at room temperature. The reaction mixture was evaporated at <50° C. The reaction mixture was poured into crushed ice and treated with concentrated hydrochloric acid. The separated aqueous layer was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 29 parts (100%) of 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid as a residue (int. 33).

Workup

  1. temperaturecooled
  2. additionUpon complete addition
  3. stirringstirring
  4. customThe reaction mixture was evaporated at <50° C
  5. additionThe reaction mixture was poured
  6. custominto crushed ice
  7. additiontreated with concentrated hydrochloric acid
  8. extractionThe separated aqueous layer was extracted with dichloromethane
  9. customThe extract was dried
  10. filtrationfiltered
  11. customevaporated

Sources & evidence

ORD record
ord-c813736bd6e74d8fb358b0f1a9274a36
Source dataset
uspto-grants-1992_04
Patent number
US05106973

Reaction notes

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