HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (Phenylmethyl) 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid | HCID 9895315 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Phenylmethyl) 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate | HCID 12674069 | 91.5% |
Reaction Steps
To a stirred mixture of 29 parts of 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid and 520 parts of dichloromethane were added dropwise 14.9 parts of thionyl chloride. Upon complete addition, stirring was continued overnight at room temperature. The reaction mixture was evaporated, yielding 28.3 parts (91.5%) of (phenylmethyl) 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate as a residue (int. 34).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05106973 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-6e8d6cab5dae4a3eadb052a7e0a33ad3 |
| Source note | uspto-grants-1992_04 |