HCID 14989206, compound → HCID 14989207, compound

HRID 1030908Notes

Reaction equation

HRID 1030908 reaction equation
[CH3:1][C:2]1([CH3:30])[CH2:6][O:5][C:4]([C:7]2[CH:29]=[CH:28][C:10]([O:11][CH2:12][CH2:13][CH2:14][CH:15]3[CH2:20][CH2:19][N:18](CC4C=CC=CC=4)[CH2:17][CH2:16]3)=[CH:9][CH:8]=2)=[N:3]1.[H][H]>[Pd].CO>[CH3:1][C:2]1([CH3:30])[CH2:6][O:5][C:4]([C:7]2[CH:29]=[CH:28][C:10]([O:11][CH2:12][CH2:13][CH2:14][CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[CH:9][CH:8]=2)=[N:3]1

Participants

5

Reactant 2

HCID 14989206HCID 14989206, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14989207HCID 14989207, compoundYield 90.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 13.5 parts of 4-[3-[4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)phenoxy]propyl]-1-(phenylmethyl)piperidine and 200 parts of methanol was hydrogenated at normal pressure and at 50° C. with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 9.5 parts (90.9%) of 4-[3-[4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)phenoxy]propyl]piperidine as a residue (int. 74).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-f521d739e3304e9990cc7ab742e25310
Source dataset
uspto-grants-1992_04
Patent number
US05106973

Reaction notes

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