Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Alpha,alpha,alpha-trifluoro-M-toluidine hydrochloride | HCID 200755 | — |
| Product | HCID 459422 | HCID 459422 | 45% |
Reaction Steps
A mixture of 70 parts of 3-(trifluoromethyl)benzenamine hydrochloride, 26.5 parts of 2-propenenitrile and 36.5 parts of N-ethylethanamine was stirred for 2.5 hours at 180° C. After cooling to 0° C., the whole was treated with a sodium hydroxide solution. The product was extracted with dichloromethane. The extract was washed with water, dried, filtered and evaporated, yielding 34.5 parts (45%) of 3-[[3-(trifluoromethyl)phenyl]amino]propanenitrile as a residue (int. 105).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05106973 |
|---|
| Source dataset | uspto-grants-1992_04 |
|---|
| ORD ID | ord-708317595f0b4c188a3c3d06effdcb42 |
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| Source note | uspto-grants-1992_04 |
|---|
