HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]-1-hexanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 14989231 | HCID 14989231 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]-1-hexanamine | HCID 14989232 | 100% |
Reaction Steps
A mixture of 3.2 parts of 6-[4-(4,5-dihydro-2-oxazolyl)phenoxy]hexanenitrile and 80 parts of methanol, saturated with ammonia, was hydrogenated at normal pressure and at room temperature with 1 part of Raney-nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 3.2 parts (100%) of 6-[4-(4,5-dihydro-2-oxazolyl)phenoxy]hexanamine as a residue (int. 108).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05106973 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-c4bd563e291b4d08a56c9c69c2764126 |
| Source note | uspto-grants-1992_04 |