Cesium carbonate → HCID 13588531, compound

Participants

Reaction Conditions

Reaction Steps

2.21 g of cesium carbonate and 9.42 g of p-amino-thiophenol were added all at once to a solution of 17.25 g of the product of Step E in 250 ml of dimethylformamide and the mixture was heated at 85° C. for 3 hours and was then returned to room temperature. The solution was filtered and the filtrate was evaporated to dryness under reduced pressure. The oil residue was taken up in 300 ml of chloromethane and the solution was washed with hydrochloric acid and then with a saturated aqueous sodium bicarbonate solution. The oil was purified by HPLC and elution with a 6-4 cyclohexane-ethyl acetate mixture yielded the expected product.

Provenance & Evidence