m-Chloroperbenzoic acid → HCID 19819707, compound

Participants

Reaction Steps

To a stirred solution of 1.34 g (2.98 mmols) of ethyl N-(2-(4-benzyloxyphenyl)acetyl)-N-(4-methylthiophenyl)glycinate (VIIq) in 25 mL dry dichloromethane (CH2Cl2) was added 1.05 equivalents of m-chloroperoxybenzoic acid at 0° C. After stirring for 30 min., the solution was poured into 200 mL of saturated NaHCO3 solution containing 10 mL of 10% NaHCO3 solution and was extracted with two 100 mL portions of CH2Cl2. The combined organic extracts were dried over MgSO4 and concentrated to give 1.40 g (ca. 100% yield) of the sulfoxide (VIIt) was an oil.

Provenance & Evidence