Chlorine → HCID 19819658, compound

Participants

Reaction Steps

Chlorine gas was passed through a solution of 2-nitro-4-trifluoromethoxy-aniline (14.5g) in carbon tetrachloride (175ml). The stirred mixture became solid, and more carbon tetrachloride (50ml) was added. Chlorine gas was passed through the reaction mixture until thin layer chromatography on silica gel, using petroleum ether (boiling range 60-80° C.) containing ethyl acetate (30% by volume) as eluent, demonstrated the absence of starting material. Evaporation of the solvent under reduced pressure gave a dark orange solid, which on trituration with petroleum ether (boiling range 60-80° C.) gave 2-chloro-4-trifluoromethoxy-6-nitroaniline as an orange solid.

Provenance & Evidence