Water → HCID 9990570, compound

Participants

Reaction Steps

To a suspension of lithium alumimium hydride (0.2 g) in dry tetrahydrofuran (30 ml) was added a solution of the product of stage (i) (0.58 g) in tetrahydrofuran (10 ml) and the mixture was stirred at ambient temperature for 1 h. Water (0.2 ml), aqueous sodium hydroxide (2M; 0.6 ml) and water (0.2 ml) were cautiously added and the mixture was filtered. The filtrate was evaporated, the residue was dissolved in dichloromethane (20 ml), dried and evaporated in vacuo to give the title compound as an oil (0.54 g). T.l.c. SiO2 dichloromethane/methanol/ammonia (75:10:2) Rf 0.5.

Provenance & Evidence